Abstract:To broaden the research thinking and perfect the methodology of safety science, overcome the deficiencies of narrow safety model and further improve the theory system of safety science, on the perspective of safety science and macro-safety view, system safety as the starting point, “forward construct” paradigm was put forward, and the generalized safety model was constructed. Furthermore, connotation and features of the proposed model was parsed from “micro matching-micro system, middle matching-middle system, macro matching-macro system” respectively. Then, the functions and application prospects of this model were analyzed, which are: promote the research of safety systematics, promote the research of safety science principles, promote the research of accidents prevention and safety management, promote the research of construction of safety science disciplines. The results show that the proposed model is a new scientific idea and a new method of safety science research, and can be the theoretical guidance of the construction of safety science discipline system and related research.