Abstract:The development process of science and technology combined with finance in Guangdong can be divided into four stages as initial stage, exploration period, rapid development period and comprehensive development period. The research shows that the policy orientation and development priorities of Guangdong science and technology combined with finance are quite different in each stage. Through years of extensive and in-depth innovative practice in scientific and technological financial policy system construction, model pilot demonstration, service platform construction and product service innovation and other aspects, Guangdong science and technology combined with finance work has made important achievements with Guangdong characteristics, but there are also problems such as information level of science , technology and finance is low, industry regulation is not in place, the construction of professional personnel is lag and so on, finally put forwards some countermeasures to promote the deep integration of science and technology with finance.