Abstract:Mass-Innovation is the biggest new energy of economic transition,which is a successful practice of the Chinese supply-side economics. Entrepreneurship creates more employment opportunities,hedging risk produced by the economic downturn. To achieve the quality and efficiency by innovation,which can promote industrial upgrading and innovation-driven. Through public innovation,creating new demand,realizing new supply,developing new technologies,new industries and new forms and new pattern, promoting transformation of economic development mode from the traditional elements-driven and investment-driven to innovation-driven. Using SWOT analysis theory,on the basis of analyzing the advantages, disadvantages, opportunities and threats of innovation and entrepreneurship in Hubei Province, by innovating system and mechanism,cultivating subject,optimizing innovative and entrepreneurial environment and so on to put forward the strategies of improving innovative and entrepreneurial ability of Hubei Province.