Abstract:With the development of economic globalization and network information technology, the world economy has gradually shifted from a closed system to an open system, enterprise innovation is increasingly presents the characteristics of open innovation, The ability to integrate internal and external innovation resources effectively is particularly important for the innovation and development of enterprises. The ability of innovation resources integration is affected and restricted by many factors, such as system, culture, technology, social norms and so on. Efficient knowledge flow and effective cooperation network are the key factors that affect the ability of innovation resources integration under the open environment, This article combines the knowledge base and dynamic capabilities theory, from two aspects of knowledge integration ability and dynamic learning ability, An integrated analysis framework of the formation mechanism of enterprise innovation resources integration capability is build, system illustrates enterprise how to build efficient knowledge flow and effective cooperation network system under the open innovation environment, to improve the enterprise"s innovation ability and innovation performance.