Abstract:The Silk road economic belt is the communication between Chinese and western of Asia-Europe trade and cultural communication channel. It not only promotes the transmission of civilization of world"s three major religions and four big culture, but also the important channels of China to actively implement the strategy of "going out The domestic part of silk road economic belt can have an important impact on manufacturing agglomeration and will create new economic growth point to the central and western regions. First, this paper applies three methods to measure industrial concentration ,that is the location entropy, space Gini coefficient, E-G index to research and calculate the impact of the economic belt on the agglomeration of 34 manufacturing industry segment in 6 provinces (autonomous regions),that is Jiangsu, Anhui, Henan, Shanxi, Gansu, Xinjiang to research the manufacturing gather momentum. Then analysis China’s manufacturing export data and choose three chart for manufacturing industry and transportation way that E-G index significantly rise for empirical research according to the results of the measure index, finally found that the mode of transportation of the railway and ship transport on silk road is the main factors that influence the accumulation of driven manufacturing. The last part is the conclusion and suggestion.