Abstract:Innovation is the first driving force of development. Guangdong, Guangxi and Hainan deepen cooperation in science and technology on the basis of existing cooperation, which is significant to promote the construction of regional innovation system. The construction of regional innovation system in Guangdong, Guangxi and Hainan exits some problems. For example, the ability of original innovation is not strong and the allocation of scientific and technological resource is lagging behind. Besides, the motive force for innovation of enterprises is insufficient and the mechanism of organization innovation is not perfect. Furthermore, the scientific and technological intermediary service does not meet the industrial development needs, etc. Some corresponding measures of deepening scientific and technological cooperation are suggested as follows. Three governments should construct coordination mechanism and strengthen systematic innovation. Besides, enterprises should increase R&D investment and establish industry alliances. Institutions of scientific research should strengthen research and cultivate innovative talents. Organizations of scientific and technological intermediary service should build information platform and construct service system, etc.