Abstract:To provide a reference for enhancing the level of R D investment of the China"s pharmaceutical listed companies, based on the annual data of the listed companies from 2011 to 2015, thesis empirically analyzed the influence of the capital structure, the enterprise scale, the ownership structure, the R D personnel investment, the R D knowledge output and other factors on the R D investment intensity of the pharmaceutical listed companies by using STATA14.0 for panel regression analysis.The results show that R D personnel investment, enterprise scale, equity restriction of the ownership structure, R D knowledge output are positively correlated with R D investment intensity of pharmaceutical listed companies. Capital structure,ownership concentration of the ownership structure are no significant relationship with R D investment intensity of pharmaceutical listed companies. Appropriate expansion of the scale of enterprises, increasing R D personnel investment, improving the patent protection system to promote the efficient transformation of R D results, rational allocation of ownership structure and other means can improve the R D investment level of China"s pharmaceutical listed companies.