Abstract:The development of an innovative economy is an important strategy for a country or region to transform its economic development and form a sustainable development momentum. Learn from the domestic and foreign experiences and lessons of innovative economic development , summarize the connotation and characteristics of the innovation economy, aim at getting rid of the path dependence of the traditional economic development mode, and propose the System path theory from four dimensions of industry, system, culture and society from the perspective of innovation system, and then combined with Guangdong reality, advance the development path of innovation economy in Guangdong Province, put forward specific countermeasures.