Abstract:"The belt and the road initiative" was the strategy of China's opening to the outside world in the new period, local research institutes were the important technology in our country, the international Sci-Tech cooperation are the key methods about local research institutes of Sci-Tech to achieve the strategy of "the belt and road initiative". The footholds of international Sci-Tech cooperation about local research institutes were analyzed, the principle and methods and strategies of the methods and strategies of international Sci-Tech cooperation about local research institutes were put forwards.