Abstract:Firstly, This paper defines the connotation of International Science and Technology Innovation Nexus. Secondly, it analyses the external environment and basic condition for Guangzhou to construct International Science and Technology Innovation Nexus. It finds that Guangzhou is facing the external environment of Global cities accelerating innovation layout, China marching towards an innovative country and Guangdong marching towards the level of middle innovative countries and regions. It also finds that Guangzhou has the basic condition of large city scale, high developmental level, efficient labor productivity, medium R&D intensity and so on. Based on these, this paper puts forward the main functions of Guangzhou in constructing International Science and Technology Innovation Nexus.