Abstract:Based on the theory of industrial agglomeration and synergy innovation of IUR, estimates the level of synergy innovation of IUR of China's 3031 provinces(Not containing Hong Kong, Macao and Taiwan) between 2005 and 2015, and empirically test the direct and indirect effects of high- tech Industrial Agglomeration on Synergy Innovation of IUR. The results shows: Firstly, the overall level of synergy innovation of IUR is extremely low and there are significant differences between different regions. Secondly, there is an inverted "U" type direct relationship between the high-tech industry agglomeration and the level of synergy innovation of IUR, and with the rising of industry agglomeration degree, the influential effect changes from “synergistic” to "crowding-in”. Thirdly, the externality of high tech industry agglomeration will change the location choice of FDI, and then bring indirect impact on the level of synergy innovation of IUR; the indirect influence of high-tech industry agglomeration through technological market is not significant; no matter whether there is high technology industry agglomeration, the level of human capital and infrastructure promotes the level of synergy innovation of IUR. Finally, we figure out that by promoting linkage mechanism among subjects of synergy innovation of IUR,moderately controlling the level of industry agglomeration and perfecting the regional collaborative innovation environment, the capacity of synergy innovation of IUR can be further enhanced.