Abstract:In order to explore the problem of the stability of cooperative innovation in Supply and Demand Network from the perspective of knowledge spillover, this paper chosen the cooperative innovation behavior of Supply and Demand Network as the research object, and used the evolutionary game theory to construct the evolutionary game model of cooperative innovation behavior of the supply and demand network under the premise of bounded rationality firstly. Secondly, it discussed the path of evolution of the cooperative innovation behavior of supply and demand network, and used the numerical simulation method to study the factors that affect the stability of game system cooperation, finally. It is found that the evolution of cooperative innovation behavior of supply and demand enterprises is closely related to the initial payment matrix, and it is also related to the initial parameter selection of payment matrix; Knowledge input, knowledge complementarity and knowledge spillover coefficient are important factors that influences enterprise cooperative evolution. Increasing the knowledge input,the degree of knowledge complementarity and knowledge spillover coefficient can be effective to promote the cooperation of enterprise of Supply and Demand Network.