Abstract:Based on the C-D production function model and entropy method, this paper makes an empirical analysis on the rate and contribution rate of scientific and technological progress in Liaoning province.The research shows that the rate of scientific and technological progress in Colleges and universities is 1.90%, the contribution rate of regional economic development is 17.79%. Its scientific research efficiency of staff is about 3 times the efficiency of research institutions and efficiency of funds is 6 times the enterprises and 2 times the institutions. Therefore, increasing the funds and manpower of scientific research in universities has a very important role in improving the efficiency of scientific research and promoting the rapid development of regional economy.