Abstract:Innovation and entrepreneurship have become a trend in today"s economic society. Innovation, with its unique leading role, is called the father of wealth, while entrepreneurship is called the mother of wealth by directly creating economic benefits. Both have an important role to play in the national economy. As the employment of people"s livelihood is confronted with challenges in the new era, it is of great guiding significance for the innovation and entrepreneurship to apply to the employment to further advance this strategy. This paper selects the data of the three regions of China, and by means of the VAR model o to study the impact of innovation and entrepreneurship on employment. The results show that there is a close relationship between innovation, entrepreneurship and employment. Innovation can promote entrepreneurship and employment. And entrepreneurship can drive job growth in the long run. There are obvious regional differences in this mutually reinforcing relationship. In the eastern region, the average contribution rate of innovation to entrepreneurship is 49.96%, the average contribution rate to employment is 36.53%, and the average contribution rate of entrepreneurship to employment is 29.42%. The central and western regions are relatively weak; the corresponding results in the western region are 25.16%, 35.03% and 24.96%; the corresponding results in the central region are 24.93%, 32.47% and 21.46%.