Abstract:Under the new economic norm,the technological innovation is becoming the main engine and The structural reform of the supply side is becoming the necessary path to promote the Transformation and Upgrading of China''s Industrial Structure. And the internal evolution mechanism and pattern is recognized, which is related to the long-term transformation of the economic growth power. Based on the provincial panel data of 31 provinces in China from 2011 to 2015,this paper builds an econometric model for the technological innovation and industrial structure change.The results show that:(1)There is great difference among provinces in the non-agriculture and upgrading of industrial structure, and the regional development imbalance phenomenon is prominent.(2)The technological innovation has a significant effect on the non-agricultural structure of the industrial structure.(3)There is significantly positive effect between upgrading of industrial structure and technological innovation.According to the results of the study , some corresponding recommendations are put forward.