Abstract:R&D personnel input is an important input factor of science and technology in China's colleges and universities, and has a significant impact on the level of scientific and technological output.This paper is based on the scientific and technological output data of the universities directly under the Ministry of education during the past 2009-2016 years. And analyzes the influence factors of the University Science and technology output especially the patent from the number of R&D personnel by using linear model.The results show that R&D personnel input has different impacts on the scientific and technological output of universities in different regions,It is mainly embodied in the fact that R&D personnel can significantly affect the patent output of universities in Beijing, and have no impact on the patent output of non Beijing universities,However, the number of scientific papers in non Beijing universities has been positively affected by R&D staff.