Abstract:On the background of the complex global economy and China"s economy has entered a new normal development, the opening-up will carry the strategic function more of “Innovation Driven Development”, constructing new economic system of “opening leading innovation” is the long-term plan of Guangdong across the “Middle-income Trap” and achieve the sustainable development. Especially the “Supply-side Structural Reform” promoted in depth, according to the characteristics and “short board” of Guangdong independent innovation ability, we should do the following two jobs: first, independent innovation ability could be improved through the path of “Blood Transfusion”, “Hematopoiesis” “Blood Circulation”. Second, examining three paths of independent innovation capability from the system and association, then through the implementation of five kinds of collaborative strategies, to adjust the internal and external good factors to innovation in order to fully exert the synergistic effect. The conclusion of the study can provide decision-making reference for improving the system environment, improving the innovation system, establishing scientific human capital and trade policy, science technology R D policy and FDI policy of Guangdong province.