Abstract:In this paper, Taking 1615 literatures published in the journals of CSSCI and CNKI database from 1992 to 2016 as data sources,analyzes hot topics and evolution of knowledge about the University-Industry collaboration by bibliometrics and Mapping knowledge domain methods. This result suggest that (1) there are five hot topics, namely the Collaboration mode of university and industry, higher education and human training in industry-university-research cooperation, the interaction and coordination in collaborative innovation process, performance evaluation, and(2) Research topics in the field have undergone significant changes in the past two decades, from the mode of cooperation between industry and university, to the higher education\the human training, education reform, management of intellectual property rights and profit distribution among industries, universities and research institutes, to the performance evaluation of industry-university-institute cooperation, collaborative innovation and innovation cooperation network. At the same time, it has been found that the mode of industry-university-institute cooperation is a hot topic always. The research on education, transaction costs, benefit distribution and knowledge transfer have originated in about 2000, while transaction costs has less been followed at present. However, benefit distribution and knowledge transfer have received constant attention. Performance evaluation, industry-university-institute collaborative innovation, and innovation network have been studied after 2010.