Abstract:The exploration characteristic of large science projects determines that a large number of non-standard equipment will be used in the process of implementation, especially the non-standard key components. Due to the very small number of domestic key components suppliers, the suppliers of key components often have a strong voice, leading a reduction in the level of investment in the production process, which is called immoral behavior of suppliers. To solve this problem, this paper studies the quality control contract of key components procurement in large science projects based on the principal-agent theory. Through the establishment the expected return function model of key components suppliers and buyers, the optimization theory is used to solve the optimal investment level in production process of suppliers, the optimal quality inspection level of buyer, and the information rent of buyer. Results of a numerical example show that when the key components suppliers improve investment level, the quality prevention level of the key components suppliers will increase and the buyer’s quality inspection level will decrease. the buyer can encourage the key components suppliers to increase the investment level in production process by paying the information rent, the information rents presented an inverted U-shaped with the increase of the quality inspection level of buyers. Under the condition of complete information, the key components buyers and suppliers are composed of two echelon supply chain system for joint decision making. If in order to maximize the incentive for key components suppliers, significantly increasing the expected returns of the suppliers, buyers need to maintain a high-level quality inspection, but its expected returns decreased significantly; if in order to improve the overall supply chain expected returns, buyers need to maintain a relatively low-level quality inspection, the expected returns of the buyers is not significantly reduced, but the expected returns of suppliers will not significantly increased.