Abstract:How many market players will have a far-reaching impact on the formation of a new regional competitive landscape and making bigger market players, especially the total number of enterprises, is the basis for building a strong country with science and technology. This paper uses the publicly available data sources of the government to quantitatively analyze the entrepreneurial activity of enterprises in innovative domestic cities such as Chongqing and Beijing, Tianjin, Shanghai and Shenzhen from the perspectives of innovation potential, vitality and effectiveness based on the enterprise perspective. This paper studies the gap between Chongqing's innovation and entrepreneurial activity and the developed regions in eastern China based on the perspective of the enterprise, with a view to discovering the advantages and existing problems in Chongqing's innovation and entrepreneurship activities. Put forward to further promote the innovation and entrepreneurship in Chongqing to enhance the path and countermeasures.