Abstract:As a producer and transmission, science and technology service industry of science and technology plays an important role in the development of national economy. Therefore, building a science and technology service model for the development of a particular region and proposing the corresponding safeguard mechanism are of great significance to the rapid development of the regional science and technology service industry. According to the development of science and technology service industry both at home and abroad, on the basis of defining the connotation and characteristics of science and technology service industry, aiming at the current state of development of science and technology service industry in Harbin-Changchun megalopolis, combined with the theory of industrial ecology, constructed a virtuous circle of ecological science and technology service mode of "Demand Analysis - Resource Matching - Service Docking - Assessment Feedback". And provide customized development mechanism for the development of its science and technology services.