Abstract:The continuous interaction and evolution of industry-university-institute cooperative network and cooperative technology has the great significance to realize resource sharing and technological innovation. This paper takes the "211 project" colleges and universities in Jiangsu province as the research object, and studied the co-evolution of industry-university-institute patent cooperation network and technology field with the patent cooperation data and network analysis method. The results showed that the evolution of patent cooperation network in colleges and universities has led to the development of its technology research and development field,the development of technology research and development also promotes the evolution of the network structure of patent cooperation in colleges and universities, and the differences in the field of technology research and development make the evolution process of patent cooperation networks of different types of colleges and universities different;the changes in the technical field of industrial, university, research and research patent cooperation in colleges and universities are influenced by the adjustment of national policies, and the development of technology research and development in colleges and universities plays a leading role in the formation of superior subjects.