Abstract:The operating efficiency directly reflects the development status of business incubators. In this paper, data envelopment analysis (DEA) is used to research the operation efficiency of 245 business incubators in Guangdong Province. The results show that the low pure technical efficiency of is the main reason affecting the efficiency of Guangdong business incubator; In the four key cities, the operation efficiency of business incubators ranked in Shenzhen, Guangzhou, Dongguan and Foshan; The operation efficiency of private business incubator is obviously lower than the nature of state-owned enterprise and the nature of public institution; The operation efficiency of non state incubator is obviously lower than that of national incubator. Finally, suggestions are given to further promote the development of business incubators in Guangdong Province.