Abstract:Industry-university-research collaborative innovation could promote the deep integration of technology and economy and the construction of an innovation-oriented nation for China. However, the current industry-university-research collaborative innovation was still subjected to various unfavorable factors, lacking a comprehensive and in-depth discussion in the existing literatures. A coding analysis on the literatures about industry-university-research collaborative innovation from the journal database in CNKI was implemented by grounded theory. And then, the hierarchical system of obstacle factors restricting industry-university-research collaborative innovation, consisting of industry-university-research heterogeneity obstacle, industry-university-research interaction process obstacle and external environment obstacle, was constructed. And the industry-university-research heterogeneity obstacle as internal factor was an antecedent variable to industry-university-research interaction process obstacle, and the external environment obstacle reinforced the industry-university-research heterogeneity obstacle and the industry-university-research interaction process obstacle.