Abstract:Build DEA - BCC model of data envelopment analysis model and Malquist index model do static and dynamic analysis operating efficiency about 30 Chinese listed biotechnology companies from 2 011 to 2 016:Static analysis of biological technology nearly 67% in the high operational efficiency of listed companies, 33% of companies in the stage of scale increasing return, by expand the biological technology listed companies improve the management efficiency has a big space, the management efficiency become the restricting factors of companies operating efficiency; Dynamic analysis in recent years Chinese biotech total factor productivity decreased 7. 2% of listed companies, a 7. 7% decrease in technological progress become the important restrict cause of the TFP growth, 3. 4% of the total companies are restricted by the technical progress, scale efficiency and pure technical efficiency at the same time, Only restricted by scale efficiency and pure technical accounted for 3. 4% of the total, only 53% of the total number was restricted by technical progress.