Abstract:From the point of view of patent information analysis, this paper analyzes the operation of the top 10 universities with strong patent operation ability in Guangdong Province from both quantitative and qualitative aspects, including the general trend of patent operation, the time characteristics and geographical distribution of patent transfer,distribution of technical hot spots and frequency of citation, etc. The results show that, the patent operation ability of these 10 colleges and universities has been in the forefront of the national universities, but it is still necessary to further improve the patent application system, cultivate high value patents, and promote the transformation of scientific and technological achievements, plays a leading role in demonstration in patent operation of colleges and universities of Guangdong and even all over the country.