Abstract:At present, Guangdong"s regional innovation capability has leapt to the top of the country, but it is still only a major province of science and technology innovation rather than a province with strong science and technology innovation. Among them, relatively weak basic research and original innovation capabilities are important constraints for Guangdong to become a strong province for science and technology innovation. This paper starts from the connotation and requirements of building a strong province of science and technology innovation, systematically sorts out the achievements and problems in the development of Guangdong"s basic research, and proposes the policy design orientation and the promotion path for strengthening basic research in Guangdong in the new era based on the Pasteur quadrant model, and "Investment, big platform, big team, high transformation" development strategy and related suggestions.