Abstract:Under the background of biotechnology pharmaceutical industries, the paper takes a case study method, aiming at four kinds of innovative drugs that have failed to regenerate, such as thalidomide and Viagra, backtracking the rebirth process of "failure and success", and abstractly summed up "Scientists (universities, scientific research institutes) - big enterprise cooperation - Core Company", "scientist (Expert Company) - Core Company - expert company is gradually internalized into Core Company "and" scientist (Core Company) – its comprehensive action "three typical rescue paths. At last, multiple management revelations for all parties involved in biopharmaceutical innovation and failed drug recovery were put forward.