Abstract:The Pearl River Delta region is at the forefront of China’s reform and opening up, and is also the leading area for the development of technological innovation in Guangdong Province. The development of scientific and technological collaborative innovation has become an important strategic task in the Pearl River Delta region. Based on the policy background of the Pearl River Delta region and its actual conditions, this paper analyzes the current status of the input and output of scientific and technological collaborative innovation in the Pearl River Delta Region, and points out the problems and causes of the collaborative innovation in the Pearl River Delta region, and proposes a series of upgrading of the Pearl River Delta region, including the sharing of regional scientific and technological resources, the joint research of major projects, the collaborative innovation of industrial clusters, the enhancement of the vitality of science and technology agencies and the coordinated action of scientific and financial cooperation.