Abstract:Abstract: This paper analyses the coupling mechanism of regional innovation and regional economic, besides, structuring the comprehensive evaluation model of regional innovation and regional economic, and calculating the coupling coordination degrees between regional innovation and regional economic of China’s 31 provincial units with linear weighted method, and visualize the spatial patterns of the coupling coordination degrees between regional innovation and regional economic. In addition, spatial autocorrelation analysis revealed the characteristics of the coupling coordinative degree of the two systems. And spatial regression model is used to investigate the factors which affect the coordinated development of two systems. It can be concluded that: ①The overall level of regional innovation and regional economy in most of the provinces are on the rise, but the gap between provinces is expanding. ②The coupling coordinative degree of regional innovation and economy in China gradually shows that high in the east and low in the west, besides, high in the south and low in the north. ③The spatial agglomeration degree of coupling coordination degree is increasing continuously, and it presents obvious characteristics that HH agglomeration and LL agglomeration . ④Accordingly, the six factors of economic openness, government control force, human capital, scientific research environment, financial support and infrastructure have different influence on coupling coordinative degree.