Abstract:Scientific research platform is an innovative platform as an important carrier of scientific and technological resources. The overall opening and full sharing of scientific research infrastructure and scientific research instruments in Colleges and universities is conducive to improving the efficiency and benefits of the use and allocation of scientific research facilities and instruments. Based on the three helix model, this paper establishes the operation mechanism of open and sharing research platform in universities, and expounds the respective positioning of enterprises, governments and universities, and gives relevant countermeasures and suggestions, in order to provide reference for the construction of open and sharing scientific research platform in China.