Abstract:Constructing innovation and entrepreneurship education ecosystem is an important choice and way for colleges and universities to promote the implementation of innovation-driven strategy and local promotion of industrial upgrading and transformation of new and old kinetic energy under the background of new industrial revolution.Zhejiang Province has good policy conditions, innovative environment and economic basis for building an innovation and entrepreneurship education ecosystem.On this basis, with the application of new technology as the background, the key to the construction of innovation and entrepreneurship education ecosystem in colleges and universities lies in grasping the coordination mechanism of each factor in the macro, meso and micro levels and stimulating the innovation motive of each subject, optimizing the support system of innovation and entrepreneurship education ecosystem, and helping local science and technology innovation and society Economic development.