Abstract:Industry cross-space synergy innovation is a new challenge in the process of integration of global industry chain. The theoretical framework of industry trans-space synergy innovation is built based on knowledge heterogeneity. Knowledge heterogeneity is the necessary condition of industry trans-space synergy innovation, and the common knowledge base and the relative advantages of knowledge reinforce this condition. The spatial non-equilibrium of knowledge value is the basic driving force for cross-space synergy innovation. The potential knowledge gains brought by knowledge gaps promote cross-space knowledge synergy.The synergy innovation path which is called “IFSF” (“IFSF” refers to institution synergy, factor synergy, structure synergy, and function synergy) path is established in this article based on systematic view. The process of non-knowledge factors synergy, knowledge assets synergy, knowledge structure synergy, and function synergy is specificly studied.