Abstract:This paper analyzes the evolutional elements of regional innovation system and the present situation of the development of science and technology finance, taking 29 provinces of China as research samples, which are divided into five regions: northeast, southeast, northwest, central and southern regions. The evaluation index system of coordination degree of science and technology finance and science and technology innovation compound system is established, and the order degree and coordination degree of regional composite system are calculated by using synergy degree model. The results show that the coordination status of southeast region is the best, followed by the middle and south regions, the northeast and northwest regions are in a non-cooperative state with the lowest level of development. Then we set up the index system of factors influencing the cooperation degree of compound system of science and technology finance and science and technology innovation, using the spatial measurement model, introducing the spatial factors to explore the influence of each factor on the coordination of regional compound system. The result shows that the support of scientific and technological innovation is: the return of capital market, the intensity of fiscal science and technology expenditure and the competitiveness of high-tech market have a positive feedback effect on the synergy degree of regional composite system, but the influence of openness is not significant. Finally, some suggestions are put forward to promote the improvement of cooperation degree of regional composite system.