Abstract:The development of Guangdong-Hong Kong-Marco Greater Bay Area is an important opportunity for China when China enters new era. The function of " high-density technology innovation resources polymer " of Big Science Infrastructure provides a powerful grasp for the construction of Guangdong-Hong Kong-Marco Greater Bay Area. At present, the layout of Big Science Infrastructure in Guangdong-Hong Kong-Marco Greater Bay Area is decentralized. Moreover, the existing management and investment models of Big Science Infrastructure in China are not in line with the current development trend of "urban agglomeration" and "bay economy". Concentrating on the layout of Big Science Infrastructure, exploring new investment and management mode of Big Science Infrastructure, and integrating a number of national science and technology policies and strategic planning resources are the optional strategies for the construction of innovation-led development mode in the Guangdong-Hong Kong-Marco Greater Bay Area.