Abstract:In the face of how to build a national laboratory, choosing four typical national laboratories from China and United States, multi-case analysis method is used to study the project system construction method of national laboratories. The natural relationship between project system method and national laboratories’ construction is analyzed, and then combed and summarized some experiences in the project system construction method of national laboratories: The construction of the laboratories starting with the “government agenda→national strategy→projects setting”, achieving sustainable and high level advance through incremental project replacement, the resources supply based on project methods including the overall contracting and subcontracting methods. Based on the research conclusions, combined with the status quo of China's national laboratories construction, gives four optimization suggestions for the project system construction methods of national laboratories in the future, including the flexible and combined use of project-based methods, the optimal management of project groups, the plan-market duality use of project, and the platformization implementation of project.