Abstract:This paper, from the perspective of system coupling theory, consider the degree of coupling coordination between various systems of innovation elements, and the basis of talent, subject and environmental elements. The results are as follows: According to the comprehensive development level of all the sample cities, we can see that the overall coupling level of the whole sample cities is not high, and most of them are in the stage of high and moderate coupling coordination. The cities with extremely coupled coordination and low coupling coordination are few; Regional characteristics are obvious, located in the Beijing-Tianjin-Hebei region, the Yangtze River Delta region, the Pearl River Delta region cities are in the forefront, and located in the central and western regions and northeast cities are in the bottom; The cities, with the advantages of elements creating the global science and technology innovation center, like Shanghai, Beijing, Shenzhen, should get more policy support, so as to effectively promote the process of the global science and technology innovation center construction.