Abstract:The increasing demand for regional science and technology policy assessments require the rapid development of science and technology policy assessment institutions to achieve a balance between supply and demand of science and technology policy assessment services.?This paper explores the framework of regional science and technology policy evaluation institutions from macro and micro levels, and deeply analyses the construction of ”self-evaluation institutions”&”third-party institutions”in Guangdong Province and the difficulties faced by Guangdong science and technology policy assessment institutions in their development, such as relations, financial resources, systems, human resources and technology.?It is necessary to improve the regional institutional system, enhance the status of institutions, increase the financial support of institutions, strengthen institutional capacity-building, and carry out institutional supervision and evaluation in order to relieve their predicament of the development.