Abstract:In the cooperation between industry, University and research institutes, the input of science and technology and the quality of R&D are the key factors affecting the development of innovation. Under the policy framework and market environment, the subject of innovation investment and the subject of R&D obtain innovation outcome through cooperation, and gain benefits through the value of the results. Under the condition of incomplete information, the two groups form a dynamic game system. In order to study how to promote investment in science and technology and improve the quality of R&D, this paper uses evolutionary game theory to model and analyze the investment and innovation quality of science and technology, studies the mechanism of strategy selection, the interaction between investment and quality, and the main factors in the game between the input and R&D subjects in the system of science and technology innovation, and explores the ways to improve the innovation vitality and level through management improvement. Through the model analysis, it is concluded that improving the income and reward mechanism, optimizing the innovation environment and enhancing the value of innovation are essential to the healthy development of University-Research cooperation, and policy recommendations are put forward.