Abstract:Nowadays, the Guangdong-Hong Kong-Macao Greater Bay Area is ready to construct an international Bay Area and a world-class city group, which has strategic significance. The construction of university maker space could promote the construction of the International Science and Technology Innovation Center in the Guangdong-Hong Kong-Macao Greater Bay Area. However, there are still some problems in the development of top-level design, operation management and resource integration in the university maker space. Taking advantage of the open eco-location, superimposed Bay Area economy and innovative platform of the Guangdong-Hong Kong-Macao Greater Bay Area, the construction of university maker space should establish the concept of “the combination and innovation of production and universities”, improve the operation management mechanism, optimize the talent development environment and establish the spatial strategic alliance, so as to realize differentiation development, connotative development, sustainable development and shared development of university maker space.