Abstract:Knowledge diffusion is an important foundation of regional innovation. However, the conflicts of knowledge diffusion among different Innovation subjects hinder the effective allocation of knowledge resources and is not conducive to the operational efficiency of regional innovation systems.Therefore, scientific understanding and resolving the conflict of knowledge diffusion in regional innovation plays an important role in improving the operational efficiency of regional innovation system and promoting the healthy and rapid development of regional economy.Firstly, we sort out the elements and processes of knowledge diffusion in regional innovation from the perspective of social network. Secondly, the manifestations and causes of knowledge diffusion conflict are analyzed. Finally, it proposes the coordination mechanism of knowledge diffusion conflict.