Abstract:This paper investigated the performance of Matthew effect in Guangdong regional innovation development from the perspectives of R&D investment intensity, patent application amount and patent authorization amount, and then used the basic thought about the formation and influence mechanism of Matthew effect in Sociology to make an exploratory analysis on the causes of Matthew effect in Guangdong regional innovation development. As a result, this paper pointed out that the conformity of market mechanism, the inclination of regional policy, the requirement of innovation achievements, and the single evaluation mechanism are the main causes, and put forward some policy recommendations, such as strengthening the government's regulation, unclogging linkage and cooperation channel, and optimizing the evaluation and monitoring mechanism, in order to reduce the negative impact of Matthew effect in Guangdong regional innovation development.