Abstract:[purpose/significance]Using the ideas and methods of solving problems by using the theory of inventive problem solving to analyze the public opinion management of drug safety, it is found that the theory can better solve the problems in guiding public opinion of drug safety. [Method/process] On the basis of analyzing the functional model of drug safety public opinion guidance demand, drawing lessons from the characteristics of parameters in different fields of management, through comparison, analysis and screening, the parameter indicators describing drug safety public opinion guidance management are constituted, and the rationality of the construction of drug safety public opinion guidance system is demonstrated through case analysis. [Result/Conclusion] Based on the eight evolutionary rules, functional analysis and resource analysis guided by drug safety and public opinion, combined with the parameter characteristics and parameter selection principles of different management fields, 29 management parameters for drug safety public opinion guidance were proposed.