Abstract:To cause major research infrastructures play a bigger role in the construction of China's innovation system, this article has explored and investigated a number of different types of strategic league of major research infrastructure newly established in developed countries and regions such as Europe and the United States. Their functional goals and construction path have been compared and analyzed. Research found that strategic league of major research infrastructure may play a better role in promoting regional development strategies, constructing cooperative ecological network systems, promoting collaborative innovation of key technologies, coordinating facility operation management, and cooperating with data opening and sharing. The construction path may be led by scientists or government. During the construction and management process, the opinions and suggestions of stakeholders will be fully taken into account to ensure that the development of the facility can benefit multiple aspects. It also proposed the establishment of strategic league of major research infrastructure on accelerator-based photon source in China to innovate management style for optimizing collaborative management of light source. And we hope that the suggestions can be referenced to decision makers of R&D policy.