Abstract:International science and technology cooperation base is an important platform for China to carry out international scientific and technological cooperation, and it plays a leading and exemplary role in scientific and technological cooperation. Taking 20 national-level and 44 provincial-level international scientific and technological cooperation bases in Anhui Province as examples, this paper analyses the overall development and management of the base, summarizes the general characteristics of the operation of the base and the main problems in policy, construction ideas, communication channels and personnel construction, and puts forward some suggestions to improve the construction and management of the base, such as increasing financial investment, strengthening team building, strengthening exchanges and sharing, and speeding up the construction of think tanks, etc. This paper aims to further improve the base management, promote base construction, so as to promote the level of Anhui Province's foreign science and technology cooperation platform and build a more influential and innovative Anhui.