Abstract:In different industries throughout the various forms of innovation network, the network is constantly engaged in knowledge exchange and cooperation and innovation, for the various industries to provide impetus for scientific research and innovation. Based on the theory of social network, this paper establishes a theoretical model between innovative network structure, duality learning and disruptive innovation. The sample data source of this paper 134 Shanghai Zhangjiang "Pharmaceutical Valley" pharmaceutical industry enterprises, research institutions Patent analysis and questionnaire survey, through multiple regression analysis for empirical testing, found that the innovation network structure of the location of the center, Network stability and network structure hole on the disruptive innovation has a significant positive impact, The use of learning plays an intermediary role between the three sub-variables of innovation network structure, network stability, network structure hole and disruptive innovation, and exploratory learning plays an intermediary role between location center, network stability and disruptive innovation, and there is no intermediary effect between network structure hole and disruptive innovation. In order to help enterprises by improving the nature of innovative network structure, to promote disruptive innovation.