Abstract:The enterprise science and technology commissioner system has become an important driving force for Guangdong to fully implement the innovation-driven strategy work, and has formed a good development trend. The symbiotic development between enterprise science and technology commissioners and enterprises is an important factor affecting the cooperation between them.Based on symbiosis theory , this paper constructs a theoretical analysis framework of symbiosis between enterprises and enterprises in Guangdong enterprises. On the basis of this, analyzing the mutual relationship between symbiotic elements, and revealing the symbiotic mechanism of Guangdong enterprises' science and technology commissioners and enterprises, improving Guangdong enterprise science and technology commissioner system and promoting the realization of the symmetry and mutual benefit symbiosis model.