Abstract:The big science scientific research, big science project or large scientific infrastructure are not symbol and core of the era of big science or the big science system. With the development of science frontiers and the transformation of goal orientation, big science has gradually shifted from defense military orientation to social demand orientation. For big science, distributed facility megaprojects, multi-objective and other new forms of organization have emerged. The traditional division of big science and small science is being challenged. Small science and big science or large scientific infrastructure have developed new forms and paths of cooperation. Today, through new organizational forms,the big science is promoting the development of science and technology.