Abstract:In the background of mass innovation and entrepreneurship, innovation and entrepreneurship education has become the most important focus of talents training in universities. This article explores the difficulties faced by science and engineering colleges and universities in promoting innovation and entrepreneurship education from three aspects: the establishment of top-level institutions, a diversified talent training system, and guidance to serve the ecosystem, which aim to find an effective way to cultivate innovative and entrepreneurial talents in science and engineering universities based on new R&D institutions, and to cultivate innovative and applied talents that can adapt, support, and lead the development of local economy and society.