Abstract:strengthening the coupling between enterprise technology correspondent and enterprises is an important measure to promote industry-university cooperation and enhance the effect of cooperation.Based on the theory of coupling and synergy, this paper constructs a coupling evaluation model between enterprise science and technology commissioners and enterprises and conducts an empirical study on the cooperation between Guangdong's enterprise science and technology commissioners and enterprises. The results show that:the close relationship between Guangdong enterprise science and technology commissioners and enterprises has not yet been established, and the two sides are in a relatively disconnected state and have not formed a benign interaction.